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Side effects remain the primary challenge

There is no referral required and no in-person visit needed for most patients

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For example, hyperglycemia-induced downregulation of the E3 ubiquitin ligase WW domain-containing protein 1 (WWP1) decreases ubiquitin-dependent degradation of KLF15, a muscle-wastingrelated transcription factor, thereby elevating KLF15 levels and promoting muscle loss [51, 52]